Human Immune Responses to Adeno-Associated Virus (AAV) Vectors
نویسندگان
چکیده
منابع مشابه
Pre-Clinical Assessment of Immune Responses to Adeno-Associated Virus (AAV) Vectors
Transitioning to human trials from pre-clinical models resulted in the emergence of inhibitory AAV vector immune responses which has become a hurdle for sustained correction. Early animal studies did not predict the full range of host immunity to the AAV vector in human studies. While pre-existing antibody titers against AAV vectors has been a lingering concern, cytotoxic T-cell (CTL) responses...
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ژورنال
عنوان ژورنال: Frontiers in Immunology
سال: 2020
ISSN: 1664-3224
DOI: 10.3389/fimmu.2020.00670